What is Diabetes?
Diabetes is a chronic condition that occurs when the pancreas does not produce enough insulin, or when the body is unable to use insulin effectively. Insulin is essential for regulating blood glucose levels, and when it is insufficient or ineffective, glucose builds up in the bloodstream, resulting in hyperglycaemia.
This long-term condition affects around three million people in the UK, with the majority—approximately 85–90%—living with type 2 diabetes.
There are three main types of diabetes. Type 1 diabetes, previously known as insulin-dependent or childhood-onset diabetes, is characterised by the body’s inability to produce insulin. This happens because the immune system mistakenly attacks the insulin-producing beta cells in the pancreas. As a result, individuals with type 1 diabetes require lifelong insulin therapy, either through injections or an insulin pump.
Although there is no known cure, possible triggers include genetic factors or viral infections. Without insulin, glucose cannot enter cells for energy, leading to high blood sugar levels. Excess glucose is excreted in urine, causing frequent urination and increased thirst. The body then begins to break down fat for energy, leading to weight loss and fatigue despite adequate food intake.
Type 2 diabetes is far more common and typically develops in adults over the age of 40, although it is increasingly seen in younger individuals. In this condition, the pancreas still produces insulin, but either not enough is made or the body becomes resistant to its effects. This insulin resistance means glucose remains in the bloodstream instead of being used by cells.
Type 2 diabetes is strongly associated with lifestyle factors such as being overweight, physical inactivity, and poor diet, although it can also run in families. Many people remain undiagnosed for years, during which time elevated blood glucose levels can silently damage blood vessels and organs. Management often includes lifestyle changes such as improved diet and increased physical activity, along with oral medications, although many individuals may eventually require insulin therapy.
Gestational diabetes is a form of hyperglycaemia first identified during pregnancy. While it often resolves after childbirth, it increases the risk of developing type 2 diabetes later in life.
Normal blood glucose levels are generally considered to fall between 4–7 mmol/L, although there is ongoing debate about optimal targets. Some individuals, particularly those who have lived with diabetes for many years, may prefer slightly higher levels before bedtime to reduce the risk of hypoglycaemia during sleep.
If diabetes is not well controlled, it can lead to serious complications affecting multiple systems in the body. High blood sugar can damage the small blood vessels in the eyes, leading to diabetic retinopathy, which may result in visual impairment or blindness. The cardiovascular system is also at risk, with increased likelihood of heart disease, stroke, and blood clots. The kidneys may be affected, potentially leading to diabetic nephropathy and kidney failure.
In addition, elevated glucose levels create an environment that encourages infections, particularly in the extremities such as the feet and hands, making careful monitoring essential. Nerve damage, known as diabetic neuropathy, can also occur, leading to pain, numbness, and an increased risk of ulcers, particularly in the legs and feet.
Overall, diabetes is a serious condition that requires early diagnosis and ongoing management. Effective control through a combination of healthy diet, regular exercise, medication, and monitoring can significantly reduce the risk of complications and improve quality of life.
